فراتاکسین

FXN
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1EKG, 1LY7, 3S4M, 3S5D, 3S5E, 3S5F, 3T3J, 3T3K, 3T3L, 3T3T, 3T3X
معین‌کننده‌ها
نام‌های دیگر	FXN, CyaY, FA, FARR, FRDA, X25, frataxin
شناسه‌های بیرونی	OMIM: 606829 MGI: 1096879 HomoloGene: 47908 GeneCards: FXN
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۹ (موش)
پایان	24,257,969 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • iron chaperone activity; • 2 iron, 2 sulfur cluster binding; • oxidoreductase activity; • ferrous iron binding; • metal ion binding; • ferric iron binding; • ferroxidase activity;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • mitochondrial matrix; • میتوکندری; • L-cysteine desulfurase complex;
فرایند زیستی	• regulation of ferrochelatase activity; • positive regulation of cell population proliferation; • response to iron ion; • iron-sulfur cluster assembly; • ion transport; • positive regulation of aconitate hydratase activity; • positive regulation of cell growth; • cellular response to hydrogen peroxide; • negative regulation of release of cytochrome c from mitochondria; • positive regulation of succinate dehydrogenase activity; • protein autoprocessing; • negative regulation of apoptotic process; • small molecule metabolic process; • iron ion homeostasis; • iron incorporation into metallo-sulfur cluster; • cellular iron ion homeostasis; • heme biosynthetic process; • positive regulation of lyase activity; • GO:0048554 positive regulation of catalytic activity; • فسفرگیری اکسایشی; • mitochondrion organization; • adult walking behavior; • aerobic respiration; • embryo development ending in birth or egg hatching; • حس عمقی; • negative regulation of multicellular organism growth; • negative regulation of organ growth;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2395
	14297
	ENSG00000165060
	ENSMUSG00000059363
	Q16595
	O35943
	NM_000144، NM_001161706 NM_181425، NM_000144، NM_001161706
	NR_157400 NM_008044، NR_157400
	NP_852090 NP_000135، NP_852090
	NP_032070
	مشاهده/ویرایش موش

فراتاکسین (انگلیسی: Frataxin) یک پروتئین است که در انسان توسط ژن «FXN» کُدگذاری می‌شود.

فراتاکسین در میتوکندری جای دارد و عملکرد دقیق آن هنوز مشخص نیست، اما به نظر می‌رسد که در ساخت دسته‌جات ترکیبی آهن-سولفور نقش دارد. احتمال می‌رود که فراتاکسین یک شپرون آهن یا پروتئین ذخیره‌کننده آهن باشد.

اهمیت بالینی

کاهش بیان فراتاکسین سبب بروز بیماری کشندهٔ آتاکسی فردریش می گردد.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000059363 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Campuzano V, Montermini L, Moltò MD, Pianese L, Cossée M, Cavalcanti F, Monros E, Rodius F, Duclos F, Monticelli A, Zara F, Cañizares J, Koutnikova H, Bidichandani SI, Gellera C, Brice A, Trouillas P, De Michele G, Filla A, De Frutos R, Palau F, Patel PI, Di Donato S, Mandel JL, Cocozza S, Koenig M, Pandolfo M (Mar 1996). "Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion". Science. 271 (5254): 1423–7. doi:10.1126/science.271.5254.1423. PMID 8596916.
↑ Carvajal JJ, Pook MA, dos Santos M, Doudney K, Hillermann R, Minogue S, Williamson R, Hsuan JJ, Chamberlain S (Oct 1996). "The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase". Nature Genetics. 14 (2): 157–62. doi:10.1038/ng1096-157. PMID 8841185.
↑ Adinolfi S, Iannuzzi C, Prischi F, Pastore C, Iametti S, Martin SR, Bonomi F, Pastore A (Apr 2009). "Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS". Nature Structural & Molecular Biology. 16 (4): 390–6. doi:10.1038/nsmb.1579. PMID 19305405.

بیشتر بخوانید

Thierbach R, Drewes G, Fusser M, Voigt A, Kuhlow D, Blume U, Schulz TJ, Reiche C, Glatt H, Epe B, Steinberg P, Ristow M (Nov 2010). "The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals". The Biochemical Journal. 432 (1): 165–72. doi:10.1042/BJ20101116. PMC 2976068. PMID 20819074.
Montermini L, Rodius F, Pianese L, Moltò MD, Cossée M, Campuzano V, Cavalcanti F, Monticelli A, Palau F, Gyapay G (Nov 1995). "The Friedreich ataxia critical region spans a 150-kb interval on chromosome 9q13". American Journal of Human Genetics. 57 (5): 1061–7. PMC 1801369. PMID 7485155.
Bidichandani SI, Ashizawa T, Patel PI (May 1997). "Atypical Friedreich ataxia caused by compound heterozygosity for a novel missense mutation and the GAA triplet-repeat expansion". American Journal of Human Genetics. 60 (5): 1251–6. PMC 1712428. PMID 9150176.
Babcock M, de Silva D, Oaks R, Davis-Kaplan S, Jiralerspong S, Montermini L, Pandolfo M, Kaplan J (Jun 1997). "Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin". Science. 276 (5319): 1709–12. doi:10.1126/science.276.5319.1709. PMID 9180083.
Koutnikova H, Campuzano V, Foury F, Dollé P, Cazzalini O, Koenig M (Aug 1997). "Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin". Nature Genetics. 16 (4): 345–51. doi:10.1038/ng0897-345. PMID 9241270.
Wilson RB, Roof DM (Aug 1997). "Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue". Nature Genetics. 16 (4): 352–7. doi:10.1038/ng0897-352. PMID 9241271.
Campuzano V, Montermini L, Lutz Y, Cova L, Hindelang C, Jiralerspong S, Trottier Y, Kish SJ, Faucheux B, Trouillas P, Authier FJ, Dürr A, Mandel JL, Vescovi A, Pandolfo M, Koenig M (Oct 1997). "Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes". Human Molecular Genetics. 6 (11): 1771–80. doi:10.1093/hmg/6.11.1771. PMID 9302253.
Rötig A, de Lonlay P, Chretien D, Foury F, Koenig M, Sidi D, Munnich A, Rustin P (Oct 1997). "Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia". Nature Genetics. 17 (2): 215–7. doi:10.1038/ng1097-215. PMID 9326946.
Jiralerspong S, Liu Y, Montermini L, Stifani S, Pandolfo M (1997). "Frataxin shows developmentally regulated tissue-specific expression in the mouse embryo". Neurobiology of Disease. 4 (2): 103–13. doi:10.1006/nbdi.1997.0139. PMID 9331900.
Koutnikova H, Campuzano V, Koenig M (Sep 1998). "Maturation of wild-type and mutated frataxin by the mitochondrial processing peptidase". Human Molecular Genetics. 7 (9): 1485–9. doi:10.1093/hmg/7.9.1485. PMID 9700204.
Zühlke C, Laccone F, Cossée M, Kohlschütter A, Koenig M, Schwinger E (Jul 1998). "Mutation of the start codon in the FRDA1 gene: linkage analysis of three pedigrees with the ATG to ATT transversion points to a unique common ancestor". Human Genetics. 103 (1): 102–5. doi:10.1007/s004390050791. PMID 9737785.
Bartolo C, Mendell JR, Prior TW (Oct 1998). "Identification of a missense mutation in a Friedreich's ataxia patient: implications for diagnosis and carrier studies". American Journal of Medical Genetics. 79 (5): 396–9. doi:10.1002/(SICI)1096-8628(19981012)79:5<396::AID-AJMG13>3.0.CO;2-M. PMID 9779809.
Cossée M, Dürr A, Schmitt M, Dahl N, Trouillas P, Allinson P, Kostrzewa M, Nivelon-Chevallier A, Gustavson KH, Kohlschütter A, Müller U, Mandel JL, Brice A, Koenig M, Cavalcanti F, Tammaro A, De Michele G, Filla A, Cocozza S, Labuda M, Montermini L, Poirier J, Pandolfo M (Feb 1999). "Friedreich's ataxia: point mutations and clinical presentation of compound heterozygotes". Annals of Neurology. 45 (2): 200–6. doi:10.1002/1531-8249(199902)45:2<200::AID-ANA10>3.0.CO;2-U. PMID 9989622.
Coppola G, De Michele G, Cavalcanti F, Pianese L, Perretti A, Santoro L, Vita G, Toscano A, Amboni M, Grimaldi G, Salvatore E, Caruso G, Filla A (May 1999). "Why do some Friedreich's ataxia patients retain tendon reflexes? A clinical, neurophysiological and molecular study". Journal of Neurology. 246 (5): 353–7. doi:10.1007/s004150050362. PMID 10399865.
Branda SS, Cavadini P, Adamec J, Kalousek F, Taroni F, Isaya G (Aug 1999). "Yeast and human frataxin are processed to mature form in two sequential steps by the mitochondrial processing peptidase". The Journal of Biological Chemistry. 274 (32): 22763–9. doi:10.1074/jbc.274.32.22763. PMID 10428860.
Gordon DM, Shi Q, Dancis A, Pain D (Nov 1999). "Maturation of frataxin within mammalian and yeast mitochondria: one-step processing by matrix processing peptidase". Human Molecular Genetics. 8 (12): 2255–62. doi:10.1093/hmg/8.12.2255. PMID 10545606.
Forrest SM, Knight M, Delatycki MB, Paris D, Williamson R, King J, Yeung L, Nassif N, Nicholson GA (Aug 1998). "The correlation of clinical phenotype in Friedreich ataxia with the site of point mutations in the FRDA gene". Neurogenetics. 1 (4): 253–7. doi:10.1007/s100480050037. PMID 10732799.
Al-Mahdawi S, Pook M, Chamberlain S (Jul 2000). "A novel missense mutation (L198R) in the Friedreich's ataxia gene". Human Mutation. 16 (1): 95. doi:10.1002/1098-1004(200007)16:1<95::AID-HUMU29>3.0.CO;2-E. PMID 10874325.
Dhe-Paganon S, Shigeta R, Chi YI, Ristow M, Shoelson SE (Oct 2000). "Crystal structure of human frataxin". The Journal of Biological Chemistry. 275 (40): 30753–6. doi:10.1074/jbc.C000407200. PMID 10900192.

پیوند به بیرون

frataxin در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000059363 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8596916-4] Campuzano V, Montermini L, Moltò MD, Pianese L, Cossée M, Cavalcanti F, Monros E, Rodius F, Duclos F, Monticelli A, Zara F, Cañizares J, Koutnikova H, Bidichandani SI, Gellera C, Brice A, Trouillas P, De Michele G, Filla A, De Frutos R, Palau F, Patel PI, Di Donato S, Mandel JL, Cocozza S, Koenig M, Pandolfo M (Mar 1996). "Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion". Science. 271 (5254): 1423–7. doi:10.1126/science.271.5254.1423. PMID 8596916.

[pmid8841185-5] Carvajal JJ, Pook MA, dos Santos M, Doudney K, Hillermann R, Minogue S, Williamson R, Hsuan JJ, Chamberlain S (Oct 1996). "The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase". Nature Genetics. 14 (2): 157–62. doi:10.1038/ng1096-157. PMID 8841185.

[pmid19305405-6] Adinolfi S, Iannuzzi C, Prischi F, Pastore C, Iametti S, Martin SR, Bonomi F, Pastore A (Apr 2009). "Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS". Nature Structural & Molecular Biology. 16 (4): 390–6. doi:10.1038/nsmb.1579. PMID 19305405.