GRIN1

GRIN1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2HQW, 2NR1, 3BYA, 5H8N, 5H8H, 5H8Q, 5H8F, 5I2N, 5I2K, 5KCJ, 5KDT
معین‌کننده‌ها
نام‌های دیگر	GRIN1, GluN1, MRD8, NMDA1, NMDAR1, NR1, NMD-R1, glutamate ionotropic receptor NMDA type subunit 1, NDHMSR, NDHMSD, DEE101
شناسه‌های بیرونی	OMIM: 138249 MGI: 95819 HomoloGene: 7187 GeneCards: GRIN1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	25,209,199 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• calcium ion binding; • signaling receptor binding; • glycine binding; • calmodulin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • cation channel activity; • extracellularly glutamate-gated ion channel activity; • glutamate binding; • calcium channel activity; • NMDA glutamate receptor activity; • ion channel activity; • ionotropic glutamate receptor activity; • neurotransmitter binding; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; • amyloid-beta binding; • glutamate-gated calcium ion channel activity; • signaling receptor activity; • GO:0032403 protein-containing complex binding;
ترکیبات سلولی	• سیتوپلاسم; • postsynaptic membrane; • membrane; • سیناپس; • NMDA selective glutamate receptor complex; • neuron projection; • synaptic vesicle; • dendritic spine; • cell surface; • شبکه آندوپلاسمی; • integral component of membrane; • پوسته یاخته; • GO:0097483، GO:0097481 postsynaptic density; • integral component of plasma membrane; • سیناپس تحریکی; • پیوند میان‌یاخته‌ای; • دندریت; • synaptic cleft; • پایانه آکسون; • postsynaptic density membrane; • synaptic membrane; • glutamatergic synapse; • integral component of postsynaptic density membrane;
فرایند زیستی	• GO:1904089 negative regulation of neuron apoptotic process; • pons maturation; • synaptic transmission, glutamatergic; • regulation of respiratory gaseous exchange; • response to amphetamine; • regulation of membrane potential; • regulation of synapse assembly; • یادگیری; • positive regulation of excitatory postsynaptic potential; • response to ethanol; • calcium ion transport; • suckling behavior; • prepulse inhibition; • male mating behavior; • regulation of long-term neuronal synaptic plasticity; • adult locomotory behavior; • regulation of neuron apoptotic process; • ion transport; • حافظه; • regulation of axonogenesis; • neuromuscular process; • ionotropic glutamate receptor signaling pathway; • excitatory postsynaptic potential; • learning or memory; • رفتار اجتماعی; • regulation of neuronal synaptic plasticity; • associative learning; • واکنش یکه خوردن; • calcium ion homeostasis; • cation transport; • cellular calcium ion homeostasis; • cation transmembrane transport; • respiratory gaseous exchange by respiratory system; • regulation of synaptic plasticity; • response to morphine; • propylene metabolic process; • conditioned taste aversion; • cerebral cortex development; • GO:0015915 transport; • درد نوسیسپتیو; • olfactory learning; • regulation of cell communication; • یادگیری بصری; • ephrin receptor signaling pathway; • MAPK cascade; • regulation of dendrite morphogenesis; • ion transmembrane transport; • حافظه بلندمدت; • positive regulation of apoptotic process; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:0032320، GO:0032321، GO:0032855، GO:0043089، GO:0032854 positive regulation of GTPase activity; • calcium ion transmembrane transport; • regulation of ion transmembrane transport; • brain development; • positive regulation of calcium ion transport into cytosol; • calcium-mediated signaling; • protein heterotetramerization; • GO:0060401 calcium ion transmembrane import into cytosol; • excitatory chemical synaptic transmission; • positive regulation of reactive oxygen species biosynthetic process; • protein localization to postsynaptic membrane; • cellular response to amyloid-beta; • response to glycine; • positive regulation of cysteine-type endopeptidase activity; • regulation of NMDA receptor activity;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2902
	14810
	ENSG00000176884
	ENSMUSG00000026959
	Q05586
	P35438
	NM_000832، NM_001185090، NM_001185091، NM_007327، NM_021569، XM_005266071، XM_005266072، XM_005266073 XM_011518583، NM_000832، NM_001185090، NM_001185091، NM_007327، NM_021569، XM_005266071، XM_005266072، XM_005266073
	NM_001177657، NM_008169، NM_001372558، NM_001372559، NM_001372560، NM_001372561، NM_001372562 NM_001177656، NM_001177657، NM_008169، NM_001372558، NM_001372559، NM_001372560، NM_001372561، NM_001372562
	NP_001172019، NP_001172020، NP_015566، NP_067544، XP_005266128، XP_005266129، XP_005266130، XP_011516885 NP_000823، NP_001172019، NP_001172020، NP_015566، NP_067544، XP_005266128، XP_005266129، XP_005266130، XP_011516885
	NP_001171128، NP_032195، NP_001359487، NP_001359488، NP_001359489، NP_001359490، NP_001359491 NP_001171127، NP_001171128، NP_032195، NP_001359487، NP_001359488، NP_001359489، NP_001359490، NP_001359491
	مشاهده/ویرایش موش

گیرندهٔ گلوتامات [ان‌ام‌دی‌اِی]، زیرواحد زتا-۱ (انگلیسی: Glutamate [NMDA] receptor subunit zeta-1) یک پروتئین است که در انسان توسط ژن «GRIN1» کُدگذاری می‌شود.

پروتئینی که توسط این ژن کُد می‌شود، زیرواحد مهمی از «گیرنده‌های ان‌ام‌دی‌ای» است. این زیرواحدها با کمک هم، یک کانال یونی دریچه-لیگاندی ایجاد می‌کنند و نقش کلیدی در انعطاف‌پذیری در سیناپس‌هایی دارند که در یادگیری و حافظه مؤثرند. این ژن اگزون دارد. به نظر می‌رسد عوامل خاص یاخته‌ای در شکل‌گیری ایزوفرم‌های مختلف این پروتئین نقش داشته و در بروز گوناگونی عملکردی زیرواحدهای آن دخیل هستند.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000026959 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383.
↑ "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1".

برای مطالعهٔ بیشتر

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000026959 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1350383-4] Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (Jun 1992). "Heteromeric NMDA receptors: molecular and functional distinction of subtypes". Science. 256 (5060): 1217–21. doi:10.1126/science.256.5060.1217. PMID 1350383.

[entrez-5] "Entrez Gene: GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1".